Work

Transition-Metal-Catalyzed Deuteration via Hydrogen Isotope Exchange

Year: 2024

Type: article

Abstract: Direct hydrogen isotope exchange represents a distinctive strategy for deuterium labelling, where the protium is directly replaced by deuterium. In this graphical review, we summarize the progress in deuteration via transition-metal-catalyzed hydrogen isotope exchange. The review is organized according to the mechanism of C–H bond activation relating to the homogeneous catalysis, and heterogeneous catalysis is also discussed according to the catalyst type. Representative mechanistic processes are depicted, and proven cases for tritiation are also highlighted.

Source: SynOpen

DOI: 10.1055/a-2460-7378

Authors: Zhi-Jiang Jiang, Zhanghua Gao, Jian-Fei Bai

Institution: NingboTech University

Language: English

Topic: Chemical Reactions and Isotopes

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $340

Funders: National Natural Science Foundation of China, Ningbo Municipal Bureau of Science and Technology, Science and Technology Innovation 2025 Major Project of Ningbo