Work

Visible‐Light Enabled Synthesis of 1‐Aryl‐3‐Sulfonylmethyl‐1,2,4‐Triazoles by Arylazo Sulfones

Year: 2024

Type: article

Abstract: We present a novel and highly efficient method for synthesizing polyfunctionalized 1,2,4‐triazoles. This approach leverages visible light and arylazo sulfones in combination with N‐vinyl amides, in the environmentally friendly solvent ethyl acetate. Remarkably, the reaction proceeds without the need for (photo)catalysts, ensuring near‐perfect atom economy and producing only water as a by‐product. This method exhibits excellent functional group tolerance and can be scaled for both batch and continuous‐flow processes.

Source: Advanced Synthesis & Catalysis

DOI: 10.1002/adsc.202401251

Authors: Luca Nicchio, Lorenzo Di Terlizzi, Maurizio Fagnoni, Luc Neuville, Stefano Protti, Geraldine Masson

Institutions: Centre National de la Recherche Scientifique, Institut de Chimie des Substances Naturelles, University of Pavia, Université Paris-Saclay

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,430

Funder: Agence Nationale de la Recherche