Work

Bronchial salivary gland-type mucinous adenocarcinoma harboring a GNAS mutation: a novel lung cancer entity? A case report

Year: 2024

Type: article

Abstract: We report a case of a 65-year-old man with a 1.0-cm mass in the left main bronchus, exhibiting overlapping morphological, immunohistochemical, and genetic features with both pancreatic intraductal papillary mucinous neoplasm (IPMN) with associated invasive carcinoma and salivary gland IPMN. Based on its close proximity to the bronchial submucosal glands and the expression of NKX3.1 (an established immunohistochemical marker for mucinous acinar cells of the minor salivary glands), we propose that the tumor originates from the mucinous acinar cells of the bronchial salivary gland. Therefore, we suggest naming it bronchial salivary gland-type mucinous adenocarcinoma. Interestingly, a GNAS mutation, known as a highly specific marker for pancreatic IPMN, was detected by next-generation sequencing in our case. We believe that this tumor may represent a novel lung cancer entity.

Source: Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin

DOI: 10.1007/s00428-024-03956-9

Authors: Cuimin Chen, Huanwen Wu, Weihua Yin, Xiaoxin Shi, Yang Zhao

Institutions: Peking University, Peking University Shenzhen Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College Hospital

Language: English

Topic: Salivary Gland Tumors Diagnosis and Treatment

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,590