Work

Clinical manifestations and treatment of candidemia caused by different Candida species: a retrospective study

Year: 2024

Type: article

Abstract: Objective To analyzing of the clinical characteristics and treatment of candidemia caused by different pathogens. Methods A retrospective study was conducted with a focus on patients who had a clear diagnosis of "candidiasis" in our hospital from January 2020 to July 2023. The demographic data, past history, vital signs at onset, laboratory examination, treatment plan and prognosis were collected and analyzed. Results There was no significant difference in the age of onset or mortality of patients in the different pathogen groups (F1 = 0.26,P1 = 0.85;F2 = 3.31, P2 = 0.34) .Broad-spectrum antibiotic use, BMI, albumin, parenteral nutrition support, history of gastrointestinal surgery, history of urinary tract surgery and history of G+ coccidiosis infection were risk factors for death in patients with candidemia. WBC counts in the C. albicans and C. tropicalis groups were significantly greater (F = 3.95, P = 0.01) than those in the other groups. The C. tropicalis group had higher serum creatinine levels and shorter TTD (F1 = 8.40, P1 = 0.03; F2 = 5.03, P2 < 0.01).The efficacy of triazoles was similar to that of echinocandins (χ2 = 0.05, P = 0.81). After comparing the efficacy of triazoles and echinocandins across the four of pathogen groups, no measurable difference was detected (χ12 = 1.20, P1 = 0.75; χ22 = 0.05, P2 = 0.81) . Conclusion In addition to common risk factors such as older age and hypoproteinemia, a history of gastrointestinal and urinary surgery, a history of broad-spectrum antibiotic use, long-term parenteral nutrition support and G+ coccyxaemia may also be risk factors for death due to candidemia. Echinocandins are recommended as first-line treatments.

Source: BMC Infectious Diseases

DOI: 10.1186/s12879-024-10128-2