Work

Rett syndrome: interferon-γ to the rescue?

Year: 2024

Type: article

Abstract: Rett syndrome is a severe neurodevelopmental disorder in girls, underpinned by mutations in the X-linked gene MECP2. In their recent work (Frasca et al, 2024), Frasca and colleagues identified a novel pathway involving interferon-gamma (IFNγ) that could pave the way to potential therapies. R. Meehan and S. Pennings discuss the recent work from Frasca et al, in this issue of EMBO Mol Med, that shows that neural precursor cells rescue symptoms of Rett syndrome by activation of the Interferon γ pathway.

Source: EMBO Molecular Medicine

DOI: 10.1038/s44321-024-00154-7

Authors: Richard R Meehan, Sari Pennings

Institutions: Institute of Genetics and Cancer, MRC Human Genetics Unit, University of Edinburgh

Language: English

Topic: Genetics and Neurodevelopmental Disorders

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $6,890