Work

Copper-Catalyzed Benzothiazolyldifluoroalkylation of Arylidenemalonitriles or para-Quinone Methides

Year: 2024

Type: article

Abstract: We reported copper-catalyzed the 1,4- or 1,6-conjugate additions of arylidenemalonitriles or para-quinone methides with 2-bromodifluoromethylbenzo-1,3-thiazole for the preparation of benzothiazolyldifluoroalkyl containing (di)arylmethine compounds in moderate to excellent yields, providing a facile route for the synthesis of gem-difluoroalkylatated (di)arylmethine compounds. The synthetic utility of the current method was also demonstrated by a gram-scale reaction.

Source: Catalysts

DOI: 10.3390/catal14110777

Authors: Jilin Xiao, Ying Cai, Rongfu Xu, Fumin Liao, Jinbiao Liu

Institution: Jiangxi University of Science and Technology

Language: English

Topic: Fluorine in Organic Chemistry

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,069

Funders: National Natural Science Foundation of China, Education Department of Jiangxi Province