Work

Calcium Transport Activity of UV/H2O2-Degraded Fucoidans and Their Structural Characterization

Year: 2024

Type: article

Abstract: treatment; their calcium-chelating capacities and intestinal absorption properties were also investigated. The results showed that the calcium-chelating capacities of DFs were improved with a decrease in Mw. This was mainly ascribed to the increased carboxyl content, which was caused by free-radical-mediated degradation. Meanwhile, the conformation of DF changed from a rod-like chain to a shorter and softer chain. The thermodynamic analysis demonstrated that DF binding to calcium was spontaneously driven by electrostatic interactions. Additionally, DF-Ca chelates with lower Mw showed favorable transport properties across a Caco-2 cell monolayer and could effectively accelerate the calcium influx through intestinal enterocytes. Furthermore, these chelates also exhibited a protective effect on the epithelial barrier by alleviating damage to tight junction proteins. These findings provide an effective free-radical-related approach for the development of polysaccharide-based calcium supplements with improved intestinal calcium transport ability.

Source: Marine Drugs

DOI: 10.3390/md22110499

Authors: Biyang Zhu, Jiacheng Wang, Lijun You, Lianzhu Lin, Kuncheng Lin, Kseniya Hileuskaya

Institutions: South China University of Technology, National Academy of Sciences of Belarus, Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus

Language: English

Topic: Seaweed-derived Bioactive Compounds

Subfield: Aquatic Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,296