Work

Selectivity Control in Nitroaldol (Henry) Reaction by Changing the Basic Anion in a Chiral Copper(II) Complex Based on (S)-2-Aminomethylpyrrolidine and 3,5-Di-tert-butylsalicylaldehyde

Year: 2024

Type: article

Abstract: This article is a continuation of our previous research on the catalytic capability of a chiral copper complex based on commercially available (S)-2-aminomethylpyrrolidine and 3,5-di-tert-butylsalicylaldehyde with various counter-anions in the asymmetric Henry reaction. Our findings indicate that depending on the type of base used, chiral nitroalcohols with yields up to 98% and ee values up to 77%, as well as β-nitrostyrenes with yields up to 88%, can be produced. Additionally, it has been found that the outcome of the reaction and the catalytic properties of copper (II) complexes (S)-Cu1 and (S)-Cu2 are influenced by the structure of the aldehyde used.

Source: Molecules

DOI: 10.3390/molecules29215207

Authors: Olga V. Khromova, Lidiya V. Yashkina, Nadezhda V. Stoletova, Victor I. Maleev, Yuri N. Belokon, Vladimir A. Larionov

Institutions: A. N. Nesmeyanov Institute of Organoelement Compounds, Peoples' Friendship University of Russia

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $3,069

Funders: Russian Science Foundation, Ministry of Science and Higher Education of the Russian Federation, RUDN University