Development and evaluation of ibuprofen-loaded chitosan nanoparticles for pulmonary therapy
Year: 2024
Type: article
Abstract: Lung injuries are increasingly prevalent due to various diseases causing alveolar damage, potentially leading to respiratory disorders. This study employed an incubation method to develop nano-encapsulated ibuprofen within a chitosan matrix for targeted pulmonary therapy. The encapsulation was successful without altering the molecular structure of chitosan, and a 500 mg dose was identified as optimal through lung tissue cell viability and histological analysis. The controlled release mechanism of this formulation ensures targeted delivery to the lungs, reducing inflammation and promoting alveolar regeneration. This approach highlights the importance of dose optimization and presents a promising strategy to enhance the efficacy and safety of pulmonary treatments.
Source: Frontiers in Nanotechnology
Authors: I. Olvera Rodríguez, J. M. Mora-Muñoz, V. Pérez, J. Campos-Guillén, M. A. Gallegos-Reyes, P. García-Solís, A. Álvarez López, V. Vallejo Becerra, J. A. Rodríguez-Morales, A. J. Rodríguez-Méndez, C. Guzmán Martínez
Institution: Autonomous University of Queretaro
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,125
OpenAlex ID: W4404043642