Very Low‐Intensity Ultrasound Facilitates Glymphatic Influx and Clearance via Modulation of the TRPV4‐AQP4 Pathway
Year: 2024
Type: article
Abstract: Recently, the glymphatic system has been proposed as a mechanism for waste clearance from the brain parenchyma. Glymphatic dysfunction has previously been shown to be associated with several neurological diseases, including Alzheimer's disease, traumatic brain injury, and stroke. As such, it may serve as an important target for therapeutic interventions. In the present study, very low‐intensity ultrasound (VLIUS) (center frequency, 1 MHz; pulse repetition frequency, 1 kHz; duty factor, 1%; spatial peak temporal average intensity [I spta ] = 3.68 mW cm 2 ; and duration, 5 min) is found to significantly enhance the influx of cerebrospinal fluid tracers into the paravascular spaces of the brain, and further facilitate interstitial substance clearance from the brain parenchyma, including exogenous β‐amyloid. Notably, no evidence of brain damage is observed following VLIUS stimulation. VLIUS may enhance glymphatic influx via the transient receptor potential vanilloid‐4‐aquaporin‐4 pathway in astrocytes. This mechanism may provide insights into VLIUS‐regulated glymphatic function that modifies the natural course of central nervous system disorders related to waste clearance dysfunction.
Source: Advanced Science
Authors: Chueh‐Hung Wu, Wei‐Hao Liao, Ya‐Cherng Chu, Ming‐Yen Hsiao, Yi Kung, Jaw‐Lin Wang, Wen‐Shiang Chen
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $6,120
Awards: G1629156685, A Translational Investigation of Low Intensity Ultrasound Treatments for Brain Disorders( I ), G2260934797, G2831886795, G293963891, G312017641, G3409704496, G343563385, G417349071, G4568338379, Very Low-Intensity Ultrasound-Facilitated Glymphatic Function: a Promising Therapeutic Approach for Amyotrophic Lateral Sclerosis, Facilitating Intranasal Drug Delivery Using Very Low Intensity Ultrasound to Explore the Glymphatic Circulation in the Brain and Related Applications, A Translational Investigation of Low Intensity Ultrasound Treatments for Brain Disorders( II ), G7205188796, G7489393043, Applications of Lyophilized Platelet-Contained Biphasic Hydrogel in Treatment of the Rat Osteoarthritis Model (2nd and 3rd Years)
OpenAlex ID: W4404047130