Figure S23 from The Spatial Structure of the Tumor Immune Microenvironment Can Explain and Predict Patient Response in High-Grade Serous Carcinoma
Year: 2024
Type: other
Abstract: Fig S23. Survival analysis of unsupervised clustering of samples. Using all the features for the samples, unsupervised KMeans clustering was performed to identify tumors with similar feature patterns with the intent of comparing survival outcomes between clusters. As prior work has identified four molecular subtypes of HGSC, we limited the analysis to four clusters (cluster 0 n = 30; cluster 1 n = 27; cluster 2 n = 12; and cluster 3 n = 8). (A) Survival analyses did not show a significant difference in PFS between clusters (Table S16). (B) However, there was a significant difference (53.5 months vs. 85 months) in OS between clusters 0 (n = 30) and 1 (n = 27) (HR = 2.182, P = 0.007) (Table S16).
Authors: Lucy B. Van Kleunen, Mansooreh Ahmadian, Miriam D. Post, Rebecca J. Wolsky, Christian Rickert, Kimberly R. Jordan, Junxiao Hu, Jennifer K. Richer, Lindsay W. Brubaker, Nicole Marjon, Kian Behbakht, Matthew J. Sikora, Benjamin G. Bitler, Aaron Clauset
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4404049262