Work

Synthesis of α-fluorocinnamate derivatives as novel cathepsin S inhibitors with in vitro antiproliferative activity against pancreatic cancer cells

Year: 2024

Type: article

Abstract: = 5.79 µM and 20.75 µM, respectively. These findings underscore the potential of α-fluorocinnamate-based cysteine protease inhibitors as promising candidates for further development in targeting CatS and CatL with the aim to reduce pancreatic cancer cell proliferation.

Source: Bioorganic & Medicinal Chemistry

DOI: 10.1016/j.bmc.2024.117987

Authors: Andrea Citarella, Serena Petrella, Davide Moi, Alessandro Dimasi, Tommaso Braga, Lorenzo Ruberto, Stefano Pieraccini, Maurizio Sironi, Nicola Micale, Tanja Schirmeister, Giovanna Damia, Valerio Fasano, Alessandra Silvani, Clelia Giannini, Daniele Passarella

Institutions: University of Milan, Mario Negri Institute for Pharmacological Research, University of Messina, Johannes Gutenberg University Mainz

Language: English

Topic: Protease and Inhibitor Mechanisms

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,840

OpenAlex ID: W4404056321

FWCI: 0.775

Cites: 25

Cited by: 5

Related to: 10