Fluorescence sensing of glutathione based on the in-situ growth of carbon dots-manganese dioxide nanosheets
Year: 2024
Type: article
Abstract: Blue fluorescent carbon dots with high purity were synthesized through a one-step hydrothermal method using citric acid and ethylenediamine as raw materials and then purification by column chromatography . In-situ controllable synthesis was used to prepare carbon dots-manganese dioxide (CDs-MnO 2 ) nanosheets , with carbon dots as the seed, potassium permanganate as the manganese source and sodium citrate as the reducing agent. The as-prepared nanosheets were characterized by transmission electron microscopy , absorption spectroscopy , and fluorescence spectroscopy . It was found that MnO 2 can be degraded by Glutathione (GSH) through a redox reaction , which restores the fluorescence of CDs. A new method for determining GSH was constructed using CDs-MnO 2 fluorescence sensing . The method is simple and sensitive, with linear ranges of 0.1–5 μM and 10–60 μM, respectively, and a lowest detection limit of 0.034 μM. The method was successfully used for the determination of GSH in human serum, with satisfactory recoveries in the range of 98.9–100.1%.
Institution: Wannan Medical College
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,000
OpenAlex ID: W4404060318