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A Rare Case of CML Presenting with Isolated Thrombocytosis

Year: 2024

Type: article

Abstract: Chronic myeloid leukemia (CML) is a hematological malignancy characterized by uncontrolled granulocyte proliferation driven by the BCR-ABL mutation. Typically, CML presents with leukocytosis, anemia, and splenomegaly. 1 Thrombocytopenia or thrombocytosis may also occur, although isolated platelet abnormalities are uncommon as an initial presentation. In this case report, we present a rare case of a woman in her 50s who initially presented with metabolic encephalopathy and isolated thrombocytosis. Despite thorough investigation for essential thrombocytosis, looking for the most common mutations in ET, such as JAK2 or calreticulin 2, the etiology of her thrombocytosis remained unexplained. It was only upon the subsequent development of leukocytosis and anemia that further investigation led to the diagnosis of CML.

Source: Advances in Clinical Medical Research and Healthcare Delivery

DOI: 10.53785/2769-2779.1250

Authors: Daniel Idoate Domench, Aniket Rao, Aditya Sanjeevi, Himal Kharel, Gaby Razzouk

Institutions: Rochester General Hospital, Unity Health System

Language: English

Topic: Chronic Myeloid Leukemia Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4404060686

FWCI:

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