Work

Neutrophil elastase activates macrophage calpain as a mechanism for phagocytic failure

Year: 2024

Type: article

Abstract: Neutrophil elastase, a cystic fibrosis airway inflammation biomarker, increases macrophage Calpain activity, and Calpain inhibition partially restores the decreased phagocytosis in neutrophil elastase-challenged macrophages. Neutrophil elastase increases Calpain-2 protein, degrades the Calpain inhibitor, Calpastatin, and increases intracellular calcium as potential mechanisms of Calpain activation. This presents a novel mechanism for macrophage dysfunction relevant to cystic fibrosis.

Source: American Journal of Physiology-Lung Cellular and Molecular Physiology

DOI: 10.1152/ajplung.00132.2024

Authors: Jonathan Ma, Apparao B. Kummarapurugu, Shuo Zheng, Andrew J. Ghio, Laxmikant S. Deshpande, Judith A. Voynow