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Successful Salvage Therapy With Infliximab in Carbamazepine-Induced Toxic Epidermal Necrolysis Complicated With Severe Acute Colitis

Year: 2024

Type: article

Abstract: Toxic epidermal necrolysis (TEN) is a severe cutaneous adverse reaction to drugs. We report a case of a severe acute colitis mimicking an ulcerative colitis concomitant with carbamazepine-induced TEN. Five days of intravenous methylprednisolone did not improve the digestive symptoms. Intensified infliximab treatment led to a complete clinical and endoscopic remission. No relapse occurred after 2 years of follow-up without maintenance treatment. Our case suggests that infliximab is a new therapeutic option in this rare extracutaneous manifestation of TEN.

Source: Annals of Internal Medicine Clinical Cases

DOI: 10.7326/aimcc.2023.1144

Authors: Nassim Hammoudi, Amélie Tournier, Marie Jachiet, Jean-David Bouaziz, Jean-Marc Gornet

Institutions: Assistance Publique – Hôpitaux de Paris, Hôpital Saint-Louis

Language: English

Topic: Drug-Induced Adverse Reactions

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4404066492

FWCI:

Cites: 5

Cited by:

Related to: 10