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Thiazolopyrimidinium systems with a quaternized nitrogen atom as promising anticancer agents

Year: 2024

Type: article

Abstract: Thiazolopyrimidinium systems with a quaternized nitrogen atom are attracting increasing attention in the development of new anticancer drugs. Their unique chemical structure and potential biological properties make them promising candidates for the development of effective drugs. In recent years, researches have shown that these compounds have significant activity against various types of tumors due to their ability to interact with cellular targets, disrupting processes critical for the survival and proliferation of tumor cells. This review examines the current state of researches on thiazolopyrimidines, including synthesis, mechanisms of action, and evaluation of their antitumor potential, with an emphasis on the importance of the quaternized nitrogen atom in their biological activity.

Source: The Scientific Notes of the Pavlov University

DOI: 10.24884/1607-4181-2024-31-2-10-18

Authors: B. V. Paponov, O. S. Shemchuk, D. N. Maistrenko, O. E. Molchanov, V. V. Sharoyko, K. N. Semenov

Institutions: Russian Scientific Center of Radiology and Surgical Technologies, St Petersburg University

Language: English

Topic: Synthesis and biological activity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4404067634

FWCI:

Cites: 46

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Related to: 10