PICALM-MLLT10 fusion gene in hematological neoplasms: clinical features, current practices, and prognoses
Year: 2024
Type: article
Study design: Case Report
Abstract: INTRODUCTION: , is a rarely reported fusion gene in hematological malignancies, especially in Asian people. CASE PRESENTATIONS: fusion gene were identified at the First Affiliated Hospital, Zhejiang University School of Medicine, China between October 2019 and October 2023, with a median age of 25 years. Clinical diagnoses included acute myeloid leukemia (AML) in 2 patients, acute lymphoblastic leukemia (ALL) in 3, and mixed phenotype acute leukemia (MPAL) in 1. The prognosis of the patients was poor, and three patients died within 1 year despite of intensive treatment. CONCLUSION: can be diagnosed as AML, ALL, MPAL, and other extremely rare hematological malignancies, with mixed clinical manifestations and poor survival. Novel and intensive therapies, including hematopoietic stem cell transplantation, chimeric antigen receptor T-cell immunotherapy, and targeted agents such as the Bcl-2 inhibitor, could be considered in the future.
Source: Hematology
Authors: Ji-nuo Wang, Bangcheng Ye, Fei Cheng, Li Yang, Yongxian Hu, Gaofeng Zheng, Zhen Cai, Jian Yu, Wenjun Wu
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,557
Awards: G6093983190, G6365907954
OpenAlex ID: W4404067817