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Adult-Onset Acquired Ichthyosis Revealing an Underlying Colon Adenocarcinoma

Year: 2024

Type: article

Abstract: Acquired ichthyosis is an uncommon dermatologic disorder that presents in adulthood and is often associated with systemic conditions, including malignancies. We report the case of a 38-year-old male patient who developed diffuse scaling characterized by rhomboidal, fish-like scales predominantly affecting the trunk and limb extensors, with sparing of the flexures, palms, and soles. Initial therapeutic interventions with emollients and corticosteroids were unsuccessful. A skin biopsy confirmed the diagnosis of acquired ichthyosis, and subsequent diagnostic imaging revealed an underlying colon adenocarcinoma. Notably, the patient's family history was significant for his mother's colon adenocarcinoma, suggesting a potential genetic predisposition. This case highlights the critical importance of conducting a comprehensive diagnostic evaluation for underlying malignancies upon the diagnosis of acquired ichthyosis, particularly in patients with pertinent familial cancer histories. Although the patient was lost to follow-up, this case underscores the role of acquired ichthyosis as a potential paraneoplastic marker, emphasizing the need for early detection and management of associated malignancies.

Source: Cureus

DOI: 10.7759/cureus.73045