Tenascin-C-Matrix Metalloproteinase-3 Phenotype and the Risk of Tendinopathy in High-Performance Athletes: A Case–Control Study
Year: 2024
Type: article
Study design: Observational Study
Abstract: Background/Objectives: Tendon structure is predominantly composed of the extracellular matrix (ECM), and genetic variants in non-collagenous ECM components may influence susceptibility to tendinopathy. We investigated the potential influence of single nucleotide polymorphisms (SNPs) in fibrillin-2 (FBN2), tenascin-C (TNC), and matrix metalloproteinase-3 (MMP3) on the tendon regeneration failure phenotype and impact on the susceptibility to tendinopathy in Brazilian high-performance athletes. Methods: This case–control study was conducted with 397 high-performance athletes from different sports modalities (197 tendinopathy cases and 200 controls), and they were analyzed by validated TaqManTM SNP genotyping assays of the SNPs FBN2 (rs331079), TNC (rs2104772), and MMP3 (rs591058). Results: Out of the 197 tendinopathy cases, 63% suffered from chronic tendon pain and 22% experienced more than three episodes of disease manifestation. The TNC-rs2104772-A allele was significantly associated with tendinopathy (OR: 1.4; 95% CI: 1.1–1.8), while athletes carrying the MMP3-rs591058-T allele were linked to an increased risk of more episodes of disease manifestation (OR: 1.7; 95% CI: 1.1–2.8). The TNC-MMP3 tendon regeneration failure phenotype (TNC-A/MMP3-T) was associated with an increased risk of tendinopathy (OR: 1.4; 95% CI: 1.1–2.0) and episodes of disease manifestation (OR: 2.0; 95% CI: 1.2–3.5). Athletes with tendinopathy who had the TNC-A/MMP3-T interaction were more prone to experiencing more than three disease exacerbations (OR: 4.3; 95% CI: 1.8–10.5) compared to TNC-A/TNC-C. Conclusions: This study suggests that rs2104772 and rs591058 SNPs could be involved in the tendon regeneration failure phenotype and may influence the molecular mechanism related to the regulation of the tendon ECM during training workload.
Source: Diagnostics
Institutions: Universidade do Estado do Rio de Janeiro, Fundação Oswaldo Cruz, Instituto Nacional de Traumatologia e Ortopedia, Instituto Português de Oncologia Francisco Gentil, IPO Porto, Centro de Investigação do Instituto Português de Oncologia do Porto Francisco Gentil, Fernando Pessoa University, Universidade do Porto, Instituto de Ciências Biomédicas Albel Salazar
Language: English
Subfield: Orthopedics and Sports Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,955
Funders: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro, Ministério da Ciência, Tecnologia e Ensino Superior, Universidade do Estado do Rio de Janeiro, Fundação para a Ciência e a Tecnologia
Awards: G1469223174, G1840770272, G2311368543, G2525137373, Tumour coagulome and venous thromboemblism-related biomarkers for progressis assessment of ovarian cancer patiens, G2800970566, G2841036063, G348576851, G4795705108, G5853729251, G5968630590, G6731423480, G6997658380, G7156945060, G7242979404, G7328187747, G7642447115, G779182425, G7892235200, G7927636858, G8389616810, G8793604001
OpenAlex ID: W4404072425