Overexpression of bla SHV-12 caused by tandem amplification contributed to ceftazidime/avibactam resistance in hypervirulent and carbapenem-resistant Klebsiella pneumoniae
Year: 2024
Type: article
Abstract: We identified a novel ceftazidime/avibactam (CAZ/AVI) resistance mechanism in endemic sequence type 11 hypervirulent and carbapenem-resistant Klebsiella pneumoniae isolated from a patient who had not been exposed CAZ/AVI. Overexpression of blaSHV-12 caused by tandem gene amplification contributed to CAZ/AVI resistance instead of the carriage of blaKPC-2. Enhanced genomic surveillance is essential to identify emerging variants.
Source: Emerging Microbes & Infections
Authors: Chao Liu, Juan Yi, Ping Yang, Chunjing Du, Fan Jiang, Ming Lu, Pengcheng Du, Ning Shen
Institutions: Peking University Third Hospital, Peking University
Language: English
Subfield: Molecular Medicine
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,643
Awards: G6478763604, G8606015836
OpenAlex ID: W4404073226