Protective Effect of High Adherence to Mediterranean Diet on the Risk of Incident Type-2 Diabetes in Subjects with MAFLD: The [email protected] Study
Year: 2024
Type: article
Study design: Observational Study
Abstract: Background/Objectives: Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) increases the risk of Type-2 Diabetes (T2DM). The Mediterranean diet (MD) has shown advantages in the management of MAFLD and preventing co-morbidities; however, its relationship with T2DM development in MAFLD has been less investigated. We aimed to evaluate the association of MD adherence with the risk of incident T2DM in the Spanish adult population with MAFLD and according to their weight gain at 7.5 years follow-up. Methods: A cohort of 714 participants (without weight increment: 377; with weight increment: 337) from the [email protected] cohort study with MAFLD and without T2DM at baseline were investigated. Anthropometric, sociodemographic, clinical data, and a survey on habits were recorded. OGTT and fasting blood biochemistry determinations were made. Baseline adherence to MD was estimated by the adapted 14-point MEDAS questionnaire and categorized as high and low adherence. Results: In total, 98 people developed T2DM at follow-up. The high adherence to MD was inversely associated with the development of T2DM in both the overall population (0.52 [0.31–0.87]) and subjects without weight gain at follow-up (0.35 [0.16–0.78]). Conclusions: Our results suggest the protective effect of high adherence to MD regarding the risk of T2DM in subjects with MAFLD, with this health benefit being more evident in men with the absence of weight gain. These results support the recommendations for MD use in these patients.
Source: Nutrients
DOI: 10.3390/nu16213788
Institutions: Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga, Universidad de Málaga, Universidad de Oviedo, Centre for Biomedical Network Research on Rare Diseases, Hospital Universitario Central de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias, INCLIVA Health Research Institute, University of the Basque Country, Hospital de Cruces, Hospital Clínico San Carlos, Institut Universitari d'Investigació en Atenció Primària Jordi Gol
Language: English
Topic: Nutritional Studies and Diet
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,296
Awards: G111700638, Determinación de marcadores epigenéticos asociados al desarrollo de diabetes mellitus tipo 2 en la población española, G1582432351, G1619914197, G1948355581, Incidencia de diabetes tipo 2 en el estudio [email protected]: papel de los ácidos grasos y del sistema de transporte regulado por VEGFB en el desarrollo de enfermedades metabólicas, G2765490915, G2888386582, G3026164754, G3626994915, Identificación de variaciones de secuencia y de metilación e hidroximetilación en el exoma asociadas al desarrollo de diabetes tipo 2, G3896857593, G3988509664, Incidencia de diabetes y prevalencia de diabetes monogénica en el estudio [email protected]., Valor predictivo de los miRNA séricos en el desarrollo de enfermedades metabólicas y su relación con el grado de exposición a partículas y otros contaminantes del aire, Estado de nutrición de selenio en la población española. Relación con la prevalencia e Incidencia de enfermedad tiroidea y diabetes tipo 2. Estudio [email protected], G4784852260, G5139318128, G5411925836, G5448081166, G5735330230, G5968452222, G6180909832, Estudio de los microRNAS circulantes implicados en la regulación del factor VEGF-b y su modulación por los alimentos en el estudio [email protected]. Estudio funcional in vitro y mecanismos de regulación por ácidos grasos., G7016918183, G7326942374, G7490530757, Polución del aire y riesgo de diabetes en población adulta Española. Efecto mediador de los miRNA. Estudio [email protected], G8317074267, G8419808778, G843113701, G8433461741, G8507251199, G8735638945
OpenAlex ID: W4404073286