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c ANCA Antibodies and Infective Endocarditis -Friends Or Foes?

Year: 2024

Type: article

Abstract: The differential diagnosis between granulomatosis with polyangiitis (GPA) and infective endocarditis (IE) is crucial. Both diseases show clinical similarities and serologic c-ANCA overlap. We present the case of a 45-year-old patient with inflammatory and anemic syndrome, c-ANCA positivity and initial respiratory and renal symptoms that raised the suspicion of GPA. Subsequent evolution revealed severe valve involvement and the presence of Streptococcus gallolyticus in blood cultures, confirming the diagnosis of infective endocarditis. Antibiotic treatment and surgical intervention were crucial for the patient’s recovery. This case demonstrates the importance of imaging and microbiological examinations for the correct differentiation of these diseases and the importance of a multidisciplinary approach.

Source: Internal Medicine

Authors: Luiza Buican, Silviu Stanciu, Mihaela Iordache, Diana Iancu, Ramona Constantin, Liviu Stan, Silviu Dumitrescu, Maria Magdalena Gurzun

Institutions: Spitalul Universitar de Urgenţă Militar Central Dr. Carol Davila, Carol Davila University of Medicine and Pharmacy, Titu Maiorescu University

Language: English

Topic: Infective Endocarditis Diagnosis and Management

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4404073958

FWCI:

Cites: 19

Cited by:

Related to: 10