Work

G9a promotes muscular atrophy in chronic aging and acute denervation

Year: 2024

Type: article

Abstract: Muscular atrophy accompanied by neuromuscular junction (NMJ) denervation is often observed after long-term chronic diseases and aging and is associated with substantial morbidity and mortality. Here, we report that histone methyltransferase G9a is elevated in the muscle of muscular atrophy model mice and that muscle-specific deficiency of G9a ( Ehmt2 Ckmm− KO) alleviates muscular atrophy in both aged and denervated mice. Moreover, increased nerve-to-myofiber ratios and increased Agrin-Lrp4-MuSK signaling, which maintains NMJ, are found in aged Ehmt2 Ckmm− KO mice. Together, these data suggest that G9a promotes muscular atrophy and disrupts NMJ; thus, inhibiting the G9a level may be a potential therapy for muscular atrophy.

Source: Animal Diseases

DOI: 10.1186/s44149-024-00147-6

Authors: Ying Jin, Wei Kang, Xiaoge Ji, Yihao Zhou, Ling Zheng

Institution: Wuhan University

Language: English

Topic: Muscle Physiology and Disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Natural Science Foundation of China, Huazhong University of Science and Technology, Tongji University, Tongji Medical College, Huazhong University of Science and Technology