Association of Triglyceride and Glucose Index with Non-Alcoholic Fatty Liver Disease in Type 2 Diabetes Mellitus Patients
Year: 2024
Type: article
Study design: Observational Study
Abstract: The high prevalence and inferior prognosis of T2DM patients with NAFLD make early detection of NAFLD crucial for early intervention.However, insufficient evidence exists to assess the TyG among NAFLD patients in Indonesia.This study aims to investigate the role of TyG in identifying NAFLD among patients attending a tertiary care hospital in Indonesia. METHODS Design, subjects, and research variablesThis study is an analytical observational study with a cross-sectional approach.The sample for this study was T2DM patients at the diabetes outpatient ABSTRACT Introduction: Non-alcoholic fatty liver disease (NAFLD) is significantly linked to obesity, insulin resistance (IR), metabolic syndrome, and type 2 diabetes (T2DM).There isn't a single biomarker used to diagnose NAFLD.Objectives: Analyzing the association between triglyceride and glucose index (TyG) with NAFLD in T2DM.Methods: This cross-sectional study aimed to assess the efficacy of TyG as a potential NAFLD biomarker.The study was conducted on 103 diabetes outpatient clinics at the Dr. Soetomo General Academic Hospital from August to October 2023.Sixty-seven subjects experienced steatosis, while those who did not experience steatosis were 36.The statistical analysis used in this study is binary logistic regression with p <0.05.Results: The receiver operating characteristic curves (ROC) analysis showed a TyG cut-off value of 9.334 (AUC = 0.660).Analysis of the risk of TyG on the incidence of steatosis was carried out using binary logistic regression.The results showed that TyG was a significant risk factor for steatosis.Patients with a TyG value above 9.334 risk developing steatosis 3.567 times greater than patients with a TyG value below 9.334 (OR 95% = 1.373 -9.270, p = 0.009).Conclusion: A significant association between TyG and NAFLD in T2DM patients, which the TyG index may be a more effective, valuable, and uncomplicated measure for detecting and controlling NAFLD.
Source: Pharmacognosy Journal
Institutions: Universitas Airlangga, Rumah Sakit Dokter Soetomo
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4404078596