Figure 2 from Intraoperative Guidance of Pancreatic Cancer Resection Using a Toll-like Receptor 2–Targeted Fluorescence Molecular Imaging Agent
Year: 2024
Type: other
Abstract: In vivo pharmacokinetics of 100 nmol/kg TLR2L-800 in mice bearing subcutaneous TLR2+ (SU.86.86) pancreatic tumor xenografts on the right flank. A, The uptake of TLR2L-800 was observed in the tumor (yellow arrow), kidneys (white arrows), and surrounding tissue in representative in vivo fluorescence images acquired from 0 to 24 hours. For confirmation of in vivo TLR2L-800 uptake, tumor and kidneys were also imaged ex vivo at 24 hours. Graphs show the in vivo clearance profiles for (B) tumor, which exhibited a two-phase exponential decay linefit, whereas clearance from the (C) tissue and (D) kidney was best fitted by a one-phase exponential decay equation (n = 9). Note: refer to Table 1 for statistical data of the in vivo clearance profile graphs.
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
OpenAlex ID: W4404079329