Work

C─C Coupling of Methylene Ketones with Alcohols Enabled by Fe‐Catalysis: Access to Substituted Pyrroles and Pharmaceuticals

Year: 2024

Type: article

Abstract: Herein, we have reported a sustainable and chemo‐selective strategy for the synthesis of functionalized branched alcohols. A commercially available catalytic system does not need any special ligand and liberated water and hydrogen as side products. A series of alkyl primary alcohols (C4–C10), including methanol, were tolerated in good to high yield. Sequential transformations to substituted pyrroles, chromenes and synthesis of donepezil drug were obtained (>57 entries). Preliminary mechanistic investigations were performed to understand the catalytic pathways.

Source: ChemCatChem

DOI: 10.1002/cctc.202401526

Authors: Atanu Bera, Purushotam, Lalit Mohan Kabadwal, Debasis Banerjee

Institution: Indian Institute of Technology Roorkee

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze