Omnipod 5 outcomes comparing Dexcom G6 and Freestyle Libre 2 plus users in adults with type 1 diabetes
Year: 2024
Type: article
Study design: Observational Study
Abstract: Omnipod 5 outcomes comparing Dexcom G6 and Freestyle Libre 2 plus users in adults with type 1 diabetes Omnipod 5 (OP5) is a tubeless automated insulin delivery (AID) system that was, until recently, only compatible with Dexcom G6 sensors (G6).Currently, all published evidence attesting to the efficacy of OP5 relates specifically to use with G6 sensors.1,2 In mid-2024, OP5 compatibility with Freestyle Libre 2 Plus CGM (L2+) was launched in the United Kingdom.This study aimed to compare early glycaemic outcomes, and time spent in AID mode, between those using G6 and L2+ sensors.This was a retrospective analysis of 77 adults (45 G6 and 32 L2+) with type 1 diabetes at a single centre in the UK.Baseline CGM data were collected in the 28 days prior to converting from Omnipod DASH (standalone CSII) to OP5 and compared with data from the first 28 days of AID use.CGM data were obtained from LibreView and Glooko.Clinical and demographic data were obtained from SCI Diabetes (national diabetes register).As a service evaluation of routinely collected data, this project did not require ethical approval.Paired data were compared with Wilcoxon-signed rank tests and unpaired data with Wilcoxon rank-sum test.Correlations were assessed by the Spearman correlation coefficient.Categorical data were compared by chi-squared test.Logistic regression analysis assessed independent predictors of reduction in TBR and improvement in TIR (defined as >10%).p values <0.05 were considered statistically significant.Statistical analyses were performed using R Studio (version 2023.12.1).Forty-nine (64%) were female.Median age was 43 years (IQR 32-56) and diabetes duration was 23 years (14-33).Age (p = 0.872), duration (p = 0.371), sex (p = 0.947), socioeconomic deprivation (p = 0.912) and BMI (p = 0.161) did not differ between L2+ and G6 users at baseline.Baseline CGM metrics were not significantly different between G6 and L2+ users (all p > 0.05).Time in automode did not differ between groups (G6: 99% [96-100] vs. L2+: 99 [98-100], p = 0.551) and this was also true of time in limited automode (G6: 2% [2-3] vs. L2+: 2 [1-3], p = 0.826).Changes in glucose metrics from baseline are presented in Table 1.Correlation (R)
Source: Diabetic Medicine
DOI: 10.1111/dme.15465
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,640
OpenAlex ID: W4404083110