Single-Cell Spatial Transcriptomics Reveals Cellular and Molecular Heterogeneity of Non-Small Cell Lung Cancer
Year: 2024
Type: article
Abstract: Recent breakthroughs in single-cell spatial transcriptome technology have transformed biomedical research.This cutting-edge technology equips scientists to dive into the molecular details of human tissues and organs like never before.Seemingly overnight, researchers gained the power to visualize nearly every single gene in every single cell with spatial resolution, a monumental leap from previous methods, which were limited to a few genes in a few cell types.This revolution promises to deliver unprecedented insights into complex diseases such as cancer.Quickly becoming a critical tool for rapidly advancing precision medicine, the technology is helping unravel the mysteries of the local cellular environment's influence on the function and behavior of individual cells.Such fine-tuned resolution is crucial for defining baseline and conditiondependent gene expression levels across multiple cell types in healthy and diseased tissues.Since specific tissue environments depend on the various cell types of present, their proximity to each other, and the timing of signals, the ability to gain a more precise understanding of the spatial context of molecular events in intact tissues is critical.Single-cell spatial transcriptomics provides visualization and quantitation of that context at the highest possible resolution.Here we applied this revolutionary technology to explore tumor heterogeneity in non-small cell lung cancer (NSCLC) tissues.
Author: Chen Yeh
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4404083443