Year: 2024
Type: article
Abstract: The risk of developing any infection in myeloma patients is increased compared to matched controls.The increased susceptibility to infection in myeloma patients is complicated and multifactorial, probably resulting from the interplay between disease-related deficits in the innate or adaptive immune system, age-and disease-related complications and antineoplastic therapies.The majority of patients experience the first episode of severe infection before 4 months after myeloma diagnosis.The application of autologous and allogeneic stem cell transplantation and novel agents in myeloma has resulted in the emergence of infections not previously associated with myeloma.The understanding of the specific risk factors and periods during which patients are at risk of infection is the key for management of and the application of risk-adjusted prophylactic and treatment strategies.
Author: Nahla A M Hamed
Institution: Alexandria University
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4404083704