Relationship between serum 25-hydroxyvitamin D level and preeclampsia components and metabolic parameters among overweight and obese pregnant women
Year: 2024
Type: article
Study design: Observational Study
Abstract: Background: Studies have shown that vitamin D deficiency can be related to the occurrence of preeclampsia. Objective: The present study was conducted with the aim of determining the relationship between the serum level of 25-hydroxyvitamin D and preeclampsia and its related risk factors among obese or overweight pregnant women. Methods: This cross-sectional-analytical study was conducted on 83 pregnant women referring to comprehensive health service centers in Makoo city. Anthropometric indices and biochemical factors including vitamin D serum level, glycemic indices and lipid parameters were investigated in these women. In addition, the food intake of the participants was evaluated using an FFQ. Results: The results showed that there is a direct correlation between vitamin D serum level and dietary fat level (r=0.269, p=0.007) and high-density lipoprotein (HDL-C) (r=0.478, p<0.0001). Also, there was an inverse correlation between serum vitamin D level and pre-pregnancy body mass index (r=-0.625, p<0.0001), systolic blood pressure (r=-0.592, p<0.0001), diastolic blood pressure (r=-0.592, p<0.0001), fasting blood sugar (FBS) (r=-0.511, p<0.0001), proteinuria (r=-0.422, p<0.0001), triglyceride (TG) ( r=-0.225, p=0.020), total cholesterol (TC) (r=-0.428, p<0.0001) and low-density lipoprotein (LDL-C) (r=-0.602, p<0.0001). Conclusion: There is a direct relationship between dietary fat intake and serum vitamin D level. There is also a positive correlation between serum levels of this vitamin and serum HDL-C. On the other hand, there is an inverse relationship between the serum level of this vitamin and systolic blood pressure, degree of proteinuria, pre-pregnancy body mass index and FBS, TC and LDL-C.
Authors: Sepideh Dolati, Azar Mohammadi, Ali Barzegar Onsoroudi, Saeid Sadeghian, Soroosh Soroosh Nobakht Haghighi, Elaheh Foroumandi, Elnaz Jafarvand
Institutions: Tabriz University of Medical Sciences, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Islamic Azad University, Tehran, Islamic Azad University, Science and Research Branch, Sabzevar University of Medical Sciences, Tehran University of Medical Sciences
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4404086448