Work

Bi-modal confirmation of liposome delivery to the brain after focused ultrasound-induced blood-brain barrier opening

Year: 2024

Type: article

Abstract: . Passive acoustic detection during treatments revealed a correlation between acoustic signal and MRI contrast, providing a scalable metric for assessing clinical treatment efficacy in real-time. In conclusion, therapeutic ultrasound exposure can enhance delivery of large trackable nanoparticles into the brain, while enabling real-time treatment monitoring and verification.

Source: Heliyon

DOI: 10.1016/j.heliyon.2024.e39972

Authors: Chris Payne, Paul Cressey, Anisia Talianu, Elwira Szychot, Darren Hargrave, Maya Thanou, Antonios N. Pouliopoulos

Institutions: King's College London, Great Ormond Street Hospital, Pomeranian Medical University, University College London

Language: English

Topic: Ultrasound and Hyperthermia Applications

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,100

Funders: Focused Ultrasound Foundation, Children's Cancer and Leukaemia Group, LifeArc, UK Research and Innovation, Action Medical Research, Little Princess Trust, Innovate UK

Awards: G1399242631, Image-guided, focused ultrasound-triggered drug delivery technology for brain cancers, G5403490211, G6196738839, G8182745807

OpenAlex ID: W4404094812

FWCI: 1.154

Cites: 49

Cited by: 11

Related to: 10