Work

Efficacy and safety of different antiarrhythmic protocols used for rate control in dogs with secondary atrial fibrillation

Year: 2024

Type: article

Abstract: INTRODUCTION/OBJECTIVES: Studies comparing the effects of antiarrhythmic protocols used for rate control in dogs with secondary atrial fibrillation (AF) are currently limited; therefore, this study aimed to report detailed data on the efficacy and therapy-related side-effects (TRSEs) of different antiarrhythmic protocols in dogs with secondary AF. ANIMALS, MATERIALS, AND METHODS: ) were retrospectively evaluated. Signalment, clinical, diagnostic, therapeutic, and outcome data were retrieved. Electrocardiographically, antiarrhythmic efficacy was defined by a reduction in the mean heart rate on Holter monitoring ≤125 beats/minutes. Statistical analysis was performed to compare selected data, including the rate of efficacy and TRSEs as well as the median survival time, between dogs treated with different antiarrhythmic protocols. RESULTS: group (P=0.01). DISCUSSION: was well tolerated and provided clinically relevant benefits compared to the use of a single antiarrhythmic drug. LIMITATIONS: Retrospective design; heterogeneous sample size of categories analyzed; clinicopathological data available for many, but not all, dogs. CONCLUSIONS: as a first-line antiarrhythmic treatment in dogs with secondary AF.

Source: Journal of Veterinary Cardiology

DOI: 10.1016/j.jvc.2024.10.006