Work

Classifying the molecular functions of transcription factors beyond activation and repression

Year: 2024

Type: preprint

Abstract: Notch signaling is a highly conserved pathway activated by dynamic cellular interactions that initiates a molecular cascade that ultimately drives changes in gene expression. The Notch transcriptional complex (NTC) regulates genes that influence development and homeostasis. In this issue ofGenes & Development, Rogers and colleagues (doi:10.1101/gad.352108.124) leverage a rapid Notch activation system combined with molecular genomic profiling to reveal that the NTC regulates the release of paused RNA polymerase to activate direct target genes. They also highlight the role of the SWI/SNF chromatin remodeling complex in establishing and maintaining chromatin accessibility to potentiate the activation of NTC target genes.

Source: Genes & Development

DOI: 10.1101/gad.352340.124

Authors: Jinhong Dong, Michael J. Guertin

Institutions: University of Connecticut, UConn Health

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: diamond

Funder: National Institute of General Medical Sciences

Award: Mechanisms of coordinate gene regulation by transcription factors