Late Breaking Abstract - BIOMARKER ALBUMIN MODIFIED BY ISCHEMIA AS A PREDICTOR OF FUTURE CARDIOVASCULAR RISK IN PATIENTS WITH SLEEP APNEA SYNDROME AND TREATMENT WITH CPAP VS USUAL CARE TREATMENT
Year: 2024
Type: conference-abstract
Abstract: Introduction: The biomarker Ischemia Modified Albumin (IMA), accepted for the diagnosis of cardiac ischemia in adults, is considered a biomarker for direct measurement of oxidative stress, a common pathophysiological mechanism with OSA. Objetive: To assess the evolution of IMA, in terms of new cardiovascular events (CV mortality, admission for heart failure, coronary revascularization procedures, unstable angina) throughout the follow-up, depending on the baseline IMA values, severity of OSA and the treatment applied (CPAP vs conservative treatment). Methods: Nested study in the ISAAC project, a multicenter, open-label, parallel, prospective, randomized, controlled study (registration number: NCT 01335087) of patients with ACS and OSA. We included 925 patients who underwent cardiorespiratory polygraphy in the first 24-72 as well as a venous blood draw to determine IMA values. The patients were recruited consecutively and the group distribution (based on the apnea/hypopnea index [AHI]). Subsequently, patients with AHI ≥ 15 events/h were randomized to receive treatment with continuous positive airway pressure (CPAP) or conservative treatment. Conclusions: Patients with moderate-severe OSA, after being randomized to treatment with CPAP or conservative treatment, do not present a higher rate of new cardiovascular events (CV mortality, admission for CHF, coronary revascularization procedures, unstable angina) throughout follow-up, depending on high or low IMA values.
Source: Sleep Science
Institutions: Universidad de Alcalá, Hospital Universitario de Guadalajara, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Hospital Universitari Arnau de Vilanova, Hospital Universitario La Paz, Hospital La Paz Institute for Health Research, Universidad Autónoma de Madrid, Hospital Nacional de Parapléjicos, University of Castilla-La Mancha
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4404100054