Quality of life after Preoperative Home-based Exercise Training in patients with Lung Cancer: a Responder Analysis
Year: 2024
Type: conference-abstract
Abstract: A preoperative home-based exercise training (PHET) program was effective in improving health-related quality of life (HRQoL) in patients awaiting lung cancer surgery (Machado et al., Ann Surg Oncol 2023(31), 847-59), yet response variability was observed. This secondary analysis aims to explore characteristics of responders/non-responders(R/NR) and predictors of response in HRQoL to PHET. Data from a feasibility study and an RCT were analysed and included sociodemographic/clinical data (comorbidities; Incremental Shuttle Walk test; 5 times sit-to-stand; handgrip strength), European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30(EORTC-QLQ-C30). R/NR were classified using the minimal important difference (5 points) in Global HRQoL EORTC-QLQ-C30 after PHET(1-5 days before surgery). Between-group differences were analysed through independent samples t-tests, Mann–Whitney U tests, Chi-square/Fisher exact tests depending on data type/distribution. Predictors of response to PHET were analysed through a logistic regression. 32 patients (63% male, 67±8yrs) were included, 56% (n=18) R to PHET in Global QoL. R had lower Global QoL, Emotional Function and Summary Score (p<.05) and 50% had COPD (p=.019). No significant differences were found in performance variables (p>.05). In a regression model including the summary score and COPD (Nagelkerke R2=0.511), COPD was the only significant predictor: COPD patients were 13.4 times more likely to be R (OR=13.4; 95% CI 1.37; 132.17). Findings suggest that having COPD predicts response to PHET in HRQoL. Other response predictors should be investigated in larger samples.
Authors: Sara Pimenta, Pedro Machado, Cândida G. Silva, Ana Luís Garcia, Tiago Nogueira, Sónia Silva, Claúdia Lares Dos Santos, Maria Vitória Martins, André Canha, Bárbara Oliveiros, Raul A. Martins, Joana Cruz
Language: English
Topic: Cancer survivorship and care
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4404103457