Late Breaking Abstract - Prevalence and incident subclinical atherosclerosis in obstructive sleep apnea. The EPIOSA study
Year: 2024
Type: conference-abstract
Abstract: Background: Obstructive sleep apnea (OSA) is associated with cardiovascular diseases (CVD). If this may reflect differential vulnerability to early atherosclerosis is unknown. Aim. To study the impact of OSA on prevalent and incident subclinical atherosclerosis (SA) in patients without cardiovascular risk factors. Methods: 442 patients aged 20 to 70 who consecutively attended the Sleep Unit of the Hospital Miguel Servet in Zaragoza-Spain, were selected for lacking concomitant CVD or CVD risk factors and included in the EPIOSA study (GovTrials, NCT01457542111). The 10-year SCORE2 CVD risk was calculated. Bilateral carotid ultrasound were performed at baseline and every 18 to 24 months. SA was defined if ≥1 atheroma plaque was present. The relationship between OSA and SA was analyzed with multivariable regression logistic models. Development of at least ³ 1 new atheroma plaques rates were compared between those OSA patients treated and non-treated with positive airway pressure (PAP) using Cox proportional hazard models. Results: Prevalence of SA was significantly higher in OSA (AHI ³ 15 events/h) than in non-OSA group (30% vs 13% respectively). After adjusting for SCORE2, BMI, physical activity and education level, OSA patients were more likely than non-OSA to have SA (OR: 1.97; 95% CI: 1.10-3.54; P = 0.023). During a mean follow-up of 7.5 years, 26% of subjects treated with PAP develop new atheroma plaques vs 33% in patients non-treated with PAP (adjusted HR: 0.75; 95%CI, 0.37-1.58). Conclusions: OSA patients seem more vulnerable to early subclinical atherosclerosis than non-OSA. Treatment with PAP seem to slow the progression of SA in the medium-large term.
Source: Sleep Science
Institution: Hospital Universitario Miguel Servet
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4404104144