Neural processing of respiratory sensations in patients with dysfunctional breathing
Year: 2024
Type: conference-abstract
Abstract: Introduction: Dysfunctional breathing (DB) is typically characterized by dyspnea without a known underlying organic cause. Aims: We examined whether increased neural processing could partly explain the experience of such respiratory sensations. Methods: 10 DB patients (4 female, Mage=44 yrs, MFEV1%pred=102.3, Nijmegen questionnaire total score>23) and 10 healthy controls (4 female, Mage=44 yrs, MFEV1%pred=105.6) received brief inspiratory occlusions every 2nd-6th breath during unloaded breathing, to evoke respiratory-related evoked potentials (RREP) in the electroencephalogram. Results: The average mean amplitude of the RREP component N1 was larger in the DB (M=-5.03 µV, SD=3.65) compared to the control group (M=-3.22 µV, SD=1.20) with a medium effect size (Cohen’s d=-.67), but this difference did not reach statistical significance (t(18)=-1.49, p=.15). Similarly, the mean amplitude of RREP component P3 tended to be larger in the DB (M=5.20 µV, SD=4.20) compared to the control group (M=4.38 µV, SD=2.49, d=.24), but this difference was also not statistically significant (t(18)=.53, p=.60). Conclusions: While the results in this preliminary sample suggest trends for increased neural processing of respiratory sensations in DB patients, a larger sample is being collected to confirm whether these trends will reach statistical significance. erj;64/suppl_68/OA1883/F1 F1 F1
Institutions: KU Leuven, Hasselt University
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4404104208