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Investigating the impact of metabolic syndrome and its components on pancreas fat: a bidirectional Mendelian randomization study

Year: 2024
Type: article
Study design: Observational Study
Abstract: Objective: Metabolic syndrome (MetS) and fatty pancreas are 2 prevalent health conditions that are strongly associated with an elevated risk of developing type 2 diabetes, cardiovascular disease, and pancreatic cancer. Understanding the causal relationship between these conditions is important for developing effective prevention and treatment strategies. In this study, we performed a bidirectional Mendelian randomization analysis to investigate the potential causal relationship between MetS and fatty pancreas. Methods: This study undertook bidirectional Mendelian randomization. Genetic instruments for obesity, glycemic, lipid, and blood pressure were identified as instrumental variables for MetS traits in order to evaluate their causal role in pancreatic fat etiology. Summary-level data for pancreas fat (PF) were obtained from a genome-wide association study conducted in the UK Biobank. Results: There was no causal relationship between MetS as a binary trait and PF. In addition, a causal association of increasing waist-to-hip ratio (WHR) with pancreatic fat risk was found (odds ratio [OR] = 1.173, 95% confidence interval [CI]: 1.067–1.288, P = 9 × 10 −4 ]. Notably, there is no evidence of a causal relationship between PF and glycemic, lipid, and blood pressure. Sensitivity analyses did not indicate that pleiotropy was an important source of bias. Conclusion: MetS had no causal relationship with pancreatic fat. Of the components of the MetS, only abdominal obesity and pancreatic fat were observed to be causally related.
DOI: 10.1097/jp9.0000000000000202
Authors: Bohan Su, Xin Gao, Chaoyu Pang, Peng Dong, Zhiyao Fan, Hanxiang Zhan
Language: English
Subfield: Surgery
Field: Medicine
Open Access status: diamond
OpenAlex ID: W4404106908
FWCI: 0.388
Cites: 49
Cited by: 1
Related to: 10