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McArdle sign and neck flexion-induced change in central motor conduction in multiple sclerosis

Year: 2024

Type: article

Abstract: BACKGROUND: Rapidly reversible weakness with neck flexion (McArdle sign) is common in patients with multiple sclerosis (MS). The pathophysiology is unknown. OBJECTIVE: To evaluate changes in central motor conduction time (CMCT) in patients with and without McArdle sign. METHODS: We measured McArdle sign with a torque cell and CMCT with neck flexed and extended in patients with MS, other causes of myelopathy, and healthy controls. RESULTS: CMCT was prolonged with neck flexion disproportionately in those with MS-associated myelopathy (MSAM) with prominent McArdle sign compared to MS patients with lesser degrees of McArdle sign, and to controls. CONCLUSION: McArdle sign may result from stretch-induced slowing of conduction due to demyelination.

Source: Multiple Sclerosis Journal

DOI: 10.1177/13524585241295868

Authors: E Matthew Hoffman, Lucille Brown, Evan Jolliffe, Elia Sechi, William S Harmsen, Nathan D Schilaty, Brian G Weinshenker

Institutions: Mayo Clinic, University of Virginia, University of Sassari, University of South Florida

Language: English

Topic: Multiple Sclerosis Research Studies

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4404111236

FWCI: 0.532

Cites: 10

Cited by: 2

Related to: 10