Neurocognitive dysfunction in adolescents with recent onset major depressive disorder: a cross-sectional comparative study
Year: 2024
Type: article
Abstract: Objectives The aim of this study was to examine the neurocognitive deficits associated with recent onset major depressive disorder (ROD) in adolescents as compared to adult patients. Methods Cross-sectional neurocognitive data from the baseline assessments of the PRONIA study with N = 650 (55.31% females) were analyzed. We built an overall neurocognitive performance (NP) score based on a battery of eleven neurocognitive tests. We examined mean score differences in NP between the groups of healthy controls (HC) and ROD and between adolescents (15–21 years) and adults (22–40 years) within a GLM approach for unbalanced data with focus on interaction effects while controlling for effects of medication and educational years. Results We found lower NP for the ROD as compared to the HC group (d=-0.29, p = .046) and lower NP for the adolescent group as compared to the adult group (d=-0.29; p < .039). We did not find an interaction between these two group effects (F = 1.11; p = .29). Educational years explained most of the variance in the model. An aggregated score of two subtests was highly correlated with the overall score of NP (r = 0.82) Discussion Our findings suggest that the detrimental effect of ROD on neurocognitive functioning is comparable in adolescent and adult patients, since lower scores in adolescent patients are explained by effects of age and education. This has theoretical, diagnostic and treatment implications for both age groups. Conclusion Neurocognitive impairment should be seen as an important factor in ROD, however, the implications of this has so far been under addressed in clinical treatment guidelines for adolescent MDD. Neurocognitive impairment should be considered an important diagnostic issue in adolescent mental health care. Our data further suggests that efficient monitoring of neurocognitive impairment could be implemented in clinical practice by using a subset of two short tests.
Authors: Olga Bienek, Kelly Allott, Linda Antonucci, Alessandro Bertolino, Carolina Bonivento, Stephan Borgwardt, Paolo Brambilla, Katharine Chisholm, Udo Dannlowski, Theresa K. Lichtenstein, Joseph Kambeitz, Lana Kambeitz-Ilankovic, Nikolaos Koutsouleris, Rebekka Lencer, Siân Lowri Griffiths, Eleonora Maggioni, Eva Meisenzahl, Christos Pantelis, Marlene Rosen, Stephan Ruhrmann, Raimo K. R. Salokangas, Alexandra Stainton, Marian Surmann, Rachel Upthegrove, Julian Wenzel, Stephen J. Wood, Georg Romer, Jörg Michael Müller, Shalaila Haas, Alkomiet Hasan, Claudius Hoff, Ifrah Khanyaree, Aylin Melo, Susanna Muckenhuber-Sternbauer, Yanis Köhler, Ömer Öztürk, Nora Penzel, David Popovic, Adrian Rangnick, Sebastian Saldern, Rachele Sanfelici, Moritz Spangemacher, Ana Tupac, Maria Fernanda Urquijo-Castro, Johanna Weiske, Antonia Wosgien, Camilla Krämer, Karsten Blume, Dennis Hedderich, Dominika Julkowski, Nathalie Kaiser, Thorsten Lichtenstein, Ruth Milz, Alexandra Nikolaides, Tanja Pilgram, Mauro Seves, Martina Wassen, Christina Andreou, Laura Egloff, Fabienne Harrisberger, Ulrike Heitz, Claudia Lenz, Letizia Leanza, Amatya Mackintosh, Renata Smieskova, Erich Studerus, Anna Walter, Sonja Widmayer, Chris Day, Sian Lowri Griffiths, Mariam Iqbal, Mirabel Pelton, Pavan Mallikarjun, Ashleigh Lin, Alexander Denissoff, Anu Ellilä, Tiina From, Markus Heinimaa, Tuula Ilonen, Päivi Jalo, Heikki Laurikainen, Antti Luutonen, Akseli Mäkela, Janina Paju, Henri Pesonen, Reetta-Liina Säilä, Anna Toivonen, Otto Turtonen, Sonja Botterweck, Norman Kluthausen, Gerald Antoch, Julian Caspers, Hans-Jörg Wittsack, Giuseppe Blasi, Giulio Pergola, Grazia Caforio, Leonardo Fazio, Tiziana Quarto, Barbara Gelao, Raffaella Romano, Ileana Andriola, Andrea Falsetti, Marina Barone, Roberta Passiatore, Marina Sangiuliano, Ana Beatriz Solana, Manuela Abraham, Timo Schirmer, Carlo Altamura, Marika Belleri, Francesca Bottinelli, Adele Ferro, Marta Re, Emiliano Monzani, Maurizio Sberna, Giampaolo Perna, Maria Nobile, Alessandra Alciati, Armando D’Agostino, Lorenzo Del Fabro, Matteo Balestrieri, Giuseppe Cabras, Franco Fabbro, Marco Garzitto, Sara Piccin
Institutions: University Hospital Münster, The University of Melbourne, University of Bari Aldo Moro, IRCCS Eugenio Medea, University of Basel, University Hospital of Basel, University of Lübeck, University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Sussex, University of Münster, University of Cologne, University Hospital Cologne, Ludwig-Maximilians-Universität München, King's College London, Max Planck Institute of Psychiatry, University of Birmingham, Politecnico di Milano, Heinrich Heine University Düsseldorf, Melbourne Health, University of Turku, University of Oxford, Orygen
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,590
Funders: Universität Basel, Università degli Studi di Milano, Kela, Westfälische Wilhelms-Universität Münster, Universita degli Studi di Bari Aldo Moro, Turun Yliopisto, Universität zu Köln, Università degli Studi di Udine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, National Institute of Mental Health
Award: G1980742492
OpenAlex ID: W4404117924