Work

A new isoflavone from processed root barks of Paeonia suffruticosa and their procoagulant activity

Year: 2024

Type: article

Abstract: One new isoflavone, 6′-dihydroxy-2-methyl-2′-methoxyl-3′-acetylisoflavone (1) and six known compounds (2−7) were isolated from the processed root barks of Paeonia suffruticosa. The structures of these compounds were elucidated using UV, IR, NMR, and HR-ESI-MS data. Compound 1 represents the first example of naturally occurring 2-substituted isoflavone. Compounds 2−7 were isolated from the processed root barks of P. suffruticosa for the first time. In addition, all of the compounds were screened for their procoagulant activity. As a result, compounds 4, 6, and 7 showed significantly in vitro procoagulant activity.

Source: Natural Product Research

DOI: 10.1080/14786419.2024.2425044

Authors: Shuo-Guo Li, Rui Yang, Mi-Mi Lu, Shu-Mei Wang, Jiang Meng

Institution: Guangdong Pharmaceutical University

Language: English

Topic: Bioactive natural compounds

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Natural Science Foundation of China