Work

The potential role of CGRP in synuclein-associated neurodegenerative disorders

Year: 2024

Type: article

Abstract: In this hypothesis article, the potential clinicopathological associations of Calcitonin Gene Related Peptide (CGRP) with the development of synuclein-associated neurodegenerative disorders (SAND) are discussed. The presence of α-syn and CGRP in the CNS and the ENS and the intricate role of CGRP and its related pathways in inflammation, apoptosis, metabolism, neuromodulation, and brain-gut communication are analyzed. Since this hypothesis is confirmed, modulating CGRP-potential related pathways may lead to novel disease-modifying therapies.

Source: Frontiers in Neuroscience

DOI: 10.3389/fnins.2024.1479830

Authors: Athanasia Alexoudi, Vincenzo Donadio, Elissaios Karageorgiou

Institution: Neurological Institute of Athens

Language: English

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,295