Reducible Drug Pyrazinamide as a Powerful Ligand to Assist Copper (II)‐Catalyzed N‐Arylation
Year: 2024
Type: article
Abstract: ABSTRACT Herein, pyrazinamide (L1) was used as a powerful ligand to promote a CuSO4‐catalyzed reaction between aryl halides and imidazole (HID) under mild conditions, generating various N‐arylation products in good to excellent yields. The findings indicate that CuSO4 was reduced and coordinated with L1 to form [CuIL1], which activated ArX to produce [ArCuIL1X] through oxidative addition. This intermediate subsequently underwent reductive elimination to form N‐arylation products, with [ArCuILID] being generated from a reaction between [ArCuIL1X] and HID. This method was successfully extended to the synthesis of 2‐phenylindole and pyrrolo[1,2‐a]quinoxaline under mild conditions. The method significantly enhances the efficiency and cost effectiveness of C‐N coupling reaction.
Source: Applied Organometallic Chemistry
DOI: 10.1002/aoc.7874
Authors: Mengliang Chai, Sha Wang, Fengtian Wu
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4404120772