Work

Is choline kinase alpha a drug target for obesity?

Year: 2024

Type: article

Abstract: Choline kinase alpha (ChoKα) is a therapeutic target being developed for a variety of diseases, from cancer to rheumatoid arthritis and from parasites to bacterial infections. Nevertheless, the therapeutic potential of this drug target seems not exhausted and may end up as a possible solution for a larger variety of conditions. Here we present our working model for how ChoKα could play a role in obesity and for how drugs being developed as therapeutics for other diseases using ChoKα as a target, could be repurposed as prophylactic treatments for obesity. We also present preliminary observations in support of our model.

Source: Frontiers in Endocrinology

DOI: 10.3389/fendo.2024.1492753

Authors: Juan Carlos Lacal, Salam A. Ibrahim, Tahl Zimmerman

Institutions: Consejo Superior de Investigaciones Científicas, North Carolina Agricultural and Technical State University, High Point University

Language: English

Topic: Cancer, Lipids, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,295