Work

Inclusiveness of the All of Us Research Program improves polygenic risk scores and fosters genomic medicine for all

Year: 2024

Type: article

Abstract: Polygenic risk scores (PRS) show promise but have accuracy disparities across ancestries due to underrepresentation in the existing genomic databases. Here, we outline the initiative of All of Us Research Program in refining PRS and advancing genomic medicine for all. Kidenya and Mboowa discuss the current state of genomic inclusiveness in medicine. They champion the efforts of the All of Us Research Program to broaden diversity in population genomics and reduce disparities across different ancestries.

Source: Communications Medicine

DOI: 10.1038/s43856-024-00647-z

Authors: Benson R. Kidenya, Gerald Mboowa

Institutions: Catholic University of Health and Allied Sciences, African Union Commission, Africa Centres for Disease Control and Prevention, Infectious Diseases Institute, Makerere University

Language: English

Topic: Race, Genetics, and Society

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDGs: Reduced inequalities, Good health and well-being

Open Access status: gold

Estimated APC paid: $3,490