Work

Construction of α‐Ketoamides via Photoredox‐Catalyzed N−H Insertion of Amines by Sulfoxonium Ylides

Year: 2024

Type: article

Abstract: Herein, we report the development of photoredox‐catalyzed N−H insertion of sulfoxonium ylides with amines via oxidative single‐electron transfer (SET). These reactions exhibit broad substrate scope (32 examples) and offer operationally simple, scalable procedures for accessing α ‐ketoamides in a single step. Mechanistic studies and control experiments confirm the participation of a photogenerated carbon radical in facilitating the oxidative single‐electron transfer (SET) from the sulfoxonium ylides to initiate the reaction.

Source: Advanced Synthesis & Catalysis

DOI: 10.1002/adsc.202401020

Authors: Xianglin Yu, Haiyue Yang, Chang Liu, Qiping He, Zhijun Yang, Yi Jin

Institution: Yunnan University

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: National Science Foundation, National Natural Science Foundation of China, Yunnan University

Awards: G1267853476, G2724482189, G341983893