Work

p300 maintains primordial follicle activation by repressing VEGFA transcription

Year: 2024

Type: article

Abstract: In this study, our results show that p300 expression increases with primordial follicle activation. A p300 inhibitor results in premature activation of primordial follicles in cultured mouse ovaries. Conversely, the ratio of primordial follicle activation markedly decreases upon culturing with the p300 agonist. Furthermore, p300 regulates primordial follicle activation by inhibiting Vegfa transcription in granulosa cells.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00198.2024

Authors: Meina He, Yaoyun Liang, Xiaoran Nie, Tuo Zhang, Danqing Zhao, Jixian Zhang, Huan Lin, Zhirui Zeng, Xingyu Song, Yitong Wang, Shiling Ran, Shuyun Zhao, Tengxiang Chen, Chunlin Zhang, Zhanhui Feng

Institutions: Guiyang Medical University, Affiliated Hospital of Guizhou Medical University

Language: English

Topic: Reproductive Biology and Fertility

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Natural Science Foundation of China, China Postdoctoral Science Foundation, Guizhou Science and Technology Department, Guizhou Medical University, Guilin Medical University, Science and Technology Program of Guizhou Province

Awards: G1235711007, G1819315018, G1988960157, G2276507808, G2727802649, G3196528283, G3263693714, G4115323176, G4662775550, G4810805260, G5276061189, G794980755

OpenAlex ID: W4404129577

FWCI: 1.131

Cites: 75

Cited by: 3

Related to: 10