Work

Convergent and divergent immune aberrations in COVID-19, post-COVID-19-interstitial lung disease, and idiopathic pulmonary fibrosis

Year: 2024

Type: article

Abstract: Changes in the 50-gene signature, reflective of increase in CD14 + HLA-DR low CD163 + monocytes and decrease in CD4 and CD8 T cells, are associated with increased mortality in COVID-19. A reversal of this pattern can be seen in post-COVID-19-ILD, whereas its persistence can be seen in IPF. Modulating the imbalance between HLA-DR low monocytes and T cell subsets should be investigated as a potential strategy to treat pulmonary fibrosis associated with severe COVID-19 and progressive IPF.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00528.2024

Authors: Bochra Tourki, Minxue Jia, Theodoros Karampitsakos, Iset M. Vera, Alyssa Arsenault, Zainab Fatima, Carole Y. Perrot, Dylan Allen, Forouzandeh Farsaei, David Rutenberg, Debabrata Bandyopadhyay, Ricardo Restrepo-Jaramillo, Muhammad R. Qureshi, Kapilkumar Patel, Argyris Tzouvelekis, Maria G. Kapetanaki, Brenda M. Juan-Guardela, Kami Kim, Panayiotis V. Benos, Jose D. Herazo-Maya

Institutions: University of South Florida, University of Pittsburgh, Carnegie Mellon University, Tampa General Hospital, University of Patras, University of Florida

Language: English

Topic: Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Morsani College of Medicine, National Heart, Lung, and Blood Institute

Awards: Interpretable graphical models for large multi-modal COPD data (R01HL159805), G3120931812, G806062132

OpenAlex ID: W4404129587

FWCI: 2.789

Cites: 38

Cited by: 11

Related to: 10