Identifying the bioimaging features of Alzheimer’s disease based on pupillary light response-driven brain-wide fMRI in awake mice
Year: 2024
Type: article
Abstract: -driven differential analysis reveals altered visual signal processing and reduced thalamocortical activation in AD mice in comparison with wild-type (WT) control mice. In contrast, the post-illumination pupil dilation recovery-based fMRI highlights multiple brain areas associated with AD brain degeneration, including the cingulate cortex, hippocampus, septal area of the basal forebrain, medial raphe nucleus, and pontine reticular nuclei (PRN). Additionally, the brain-wide functional connectivity analysis highlights the most significant changes in PRN of AD mice, which serves as the major subcortical relay nuclei underlying oculomotor function. This work integrates non-invasive pupil-fMRI measurements in preclinical models to identify pupillary biomarkers based on brain-wide functional changes, including neuromodulatory dysfunction coupled with AD brain degeneration.
Source: Nature Communications
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $6,790
Funders: National Science Foundation, U.S. Department of Health and Human Services, Massachusetts General Hospital, National Institutes of Health, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke
Awards: Investigating the Thalamic Regulation of Neuro-Glio-Vascular Restoration Underlying Acute Coma Recovery with Multi-Modal fMRI in a Brainstem Coma Rodent Model, G1445050475, G162979332, G1823927050, Upgrade the 14T Ultrahigh Field Horizontal MR Scanner for Rodent and ex-vivo Imaging, G260613799, G3473566992, G3825361792, G5410638819, Upgrade of the Preclinical Horizontal 14T Magnet, Development of a Multi-Modal MRI Methodology to Map Paravascular Clearance Linked to Astrocyte Dysfunction in Fetal-Onset Hydrocephalus, Develop a multi-modal cross-scale fMRI platform with laminar-specific cellular recordings through multi-channel tapered photonic crystal fiber array, G6177125344, G6580186430, G731572322, Simultaneous functional MRI and Micro-Magnetic Nervous System Stimulation, G7728915618, Investigating the neurophysiological basis of circuit-specific laminar rs-fMRI, Collaborative Research: NCS-FR: Understanding the neuropeptide modulation of brain circuits by advanced nanomaterials and imaging, G8300560936, G9000113744, Local Neuronal Drive and Neuromodulatory Control of Activity in the Pial Neurovascular Circuit
OpenAlex ID: W4404130736